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Lei, Xiao M.D.



Scientist
University of Illinoisat Chicago
M/C719,840SWoodSt,Rm805
Chicago, IL 60612
(312) 996-9078(Office)
Email:leixiao@uic.edu
Not available

Affiliation with www.CNAHA.org

Lifetime member

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EDUCATION AND POSITIONS:

                  08/10-present:        Director of Research Education, Department of Medicine, Section of Pulmonary, Critical Care, Sleep and Allergy, University of Illinois at Chicago, Chicago, IL

                  06/08-present:        Assistant Professor of Medicine (Tenure-track), Department of Medicine, Sections of Pulmonary, Critical Care, Sleep and Allergy; and Cardiology, University of Illinois at Chicago, Chicago, IL.

                  04/04-05/08:          Research Assistant Professor of Medicine and Physiology, Department of Medicine, Sections of Cardiology, and Pulmonary, Critical Care and Sleep Medicine, University of Illinois at Chicago, Chicago, IL.

                  10/02-03/04:          Assistant Professor of Medicine, Department of Medicine, Cardiovascular Division, Boston University School of Medicine, Boston, MA.

                  07/01-09/02:          Instructor in Medicine, Department of Medicine, Cardiovascular Division, Boston University School of Medicine, Boston, MA.

                  10/98-06/01:          Postdoctoral Fellow, Mentor: Wilson S. Colucci, M.D., Department of Medicine, Cardiovascular Division, Boston University School of Medicine, Boston, MA.

      09/93-09/98:          Predoctoral Fellow, Mentor: William B. Jeffries, Ph.D., Department of Pharmacology, Creighton University School of Medicine, Omaha, NE.  Ph.D. was awarded in 09/98.

                  07/93-08/93:          Surgical Resident, Department of Cardiothoracic Surgery, Fuwai Hospital of Chinese Academy of Medical Sciences, Beijing, China.

                  09/87-06/93:          Medical Student, Beijing Medical University, Beijing, China. M.D. was awarded in 07/93.

HONORS AND AWARDS:

·                The Third Place Award in Faculty Category, The Northwestern University Feinberg School of Medicine Cardiovascular Young Investigators’ Forum, 2007.

·                Finalist, The Schweppe Career Development Award, The Schweppe Foundation, 2005.

·                Junior Faculty Finalist, The Northwestern University Feinberg School of Medicine Cardiovascular Young Investigators’ Forum, 2005.

·                Junior Faculty Finalist, The 9th Annual AstraZeneca Cardiovascular Young Investigators’ Forum, 2003.

·                Junior Faculty Finalist, The 6th AstraZeneca New England Cardiovascular Research Competition, 2003.

·                Young Scientist Travel Award, American Society for Pharmacology and Experimental Therapeutics, 2002.

·                Trainee Travel Grant Award, Heart Failure Society of America, 2002.

·                Jay N. Cohn New Investigator Award, Heart Failure Society of America, 2001.

·                Young Scientist Travel Award, American Society for Pharmacology and Experimental Therapeutics, 2001.

·                Trainee Travel Grant Award, Heart Failure Society of America, 2001.

·                The First Place Award, The 4th AstraZeneca New England Cardiovascular Research Competition, 2000.

·                National Research Service Award (NRSA), National Institutes of Health, 2000 to 2003.

·                Young Scientist Travel Award, American Society for Pharmacology and Experimental Therapeutics, 2000.

·                Trainee Travel Grant Award, Heart Failure Society of America, 2000.

·                The First Place Award, The 3rd AstraZeneca New England Cardiovascular Research Competition, 1999.

·                The Third Place Award, Midwest Student Biomedical Research Forum XXIX, 1998.

·                Superior Scholastic Achievement Award, Creighton University, 1996.

·                The Third Place Award, Midwest Student Medical Research Forum XXVII, 1996.

·                Outstanding Students Scholarship Award, Beijing Medical University, 1992, 1991.

RESEARCH SUPPORT:

·                5R01 HL083218 (Principal Investigator), NIH/NHLBI, “Role of p67phox in myocardial hypertrophy”, 09/03/2008 to 06/30/2013.

·                3R01 HL083218-01A2S1 (Principal Investigator), NIH/NHLBI, “Role of p67phox in myocardial hypertrophy”, 07/15/2009 to 06/30/2011.

·               Faculty Development Grant (Principal Investigator), Department of Medicine, University of Illinois at Chicago, 09/16/2006 to 09/15/2011.

·               Faculty Scholarship Support Program Grant (Principal Investigator), University of Illinois at Chicago,                                 “Toll-like receptor and NADPH oxidase in macrophages”, 05/01/09 to 10/31/11.

·               Merit Review Grant 1I01BX000108-01A1 (Co-Investigator, 10%, PI: John W. Christman) Jesse Brown VA Medical Center, “Regulation of neutrophilic lung inflammation”, 10/01/09 to 09/30/13.

·                1S10 RR027848-01     (Co-Investigator, 5%, PI: Marcelo Bonini), NIH/NCRR, “Oxidative stress imbalance in Pulmonary & Cardiovascular disease, Electron paramagnetic resonance spectrometer (EPR)”, 04/01/11-03/31/12.

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Selected publication

1.              Cao H, Xiao L, Park G, Wang X, Azim A, Christman JW, van Breemen RB: An improved LC–MS/MS method for the quantification of prostaglandins E2 and D2 production in biological fluids. Anal Biochem. 372(1):41-51, 2008.

2.              Ornatowska, M; Azim, A; Wang, X; Christman, JW; Xiao, L; Joo, M; Sadikot, R: Functional genomics of silencing TREM-1 on TLR4 signaling in macrophages. Am J Physiol Lung Cell Mol Physiol. 293:L1377–L1384, 2007.

3.              Xiao L, Zhao Q, Du Y, Chao Y, Solaro RJ, Buttrick PM: PKCe increases phosphorylation of cardiac myosin binding protein C at serine302 both in vitro and in vivo. Biochemistry 46(23):7054-7061, 2007

4.              Maytin M, Siwik DA, Ito M, Xiao L, Sawyer DB, Liao R, Colucci WS.: Pressure overload-induced myocardial hypertrophy in mice does not require gp91phox. Circulation 109(9):1168-71, 2004.

5.              Xiao L., Pimentel D.R., Wang J., Singh K., Colucci W.S., Sawyer D.B.: Role of reactive oxygen species and NAD(P)H oxidase in a1-adrenoceptor signaling in adult rat cardiac myocytes. Am J Physiol Cell Physiol, 282:C926-C934, 2002.

6.              Sawyer D.B., Siwik D.A., Xiao L., Pimentel D.R., Singh K., Colucci W.S.: Role of oxidative stress in myocardial hypertrophy and failure. J. Mol. Cell. Cardiol. 34:379-388, 2002.

7.              Zhao Q., Brauer P.R., Xiao L., McGuire M.H., Yee J.A.: Parathyroid hormone-related peptide (PTHrP) is expressed with its receptor (PTH1R) and affects the differentiation of mesenchymal cells during the histogenesis of cartilage and bone in the chicken mandibular process. J. Anat. 201:137-151, 2002.

8.              Jiao X., Gonzalez-Cabrera P.J., Xiao L., Bradley M.E., Abel P.W., Jeffries W.B.: Tonic inhibitory role for cAMP in a1a-adrenergic receptor coupling to extracellular signal-regulated kinases 1/2.  J. Pharmacol. Exp. Ther. 303:247-256, 2002.

9.              Siwik DA, Pimentel DR, Xiao L, Singh K, Sawyer DB, Colucci WS.: Adrenergic and Mechanical Regulation of Oxidative Stress in the Myocardium. In: Oxidative Stress and Cardiac Failure, Kukin ML and Fuster V (Eds.). Armonk, NY: Futura Publishing Co., Inc.: 2002: Ch. 7:153-171.

10.           Xiao L., Pimental D.R., Amin J.K., Singh K., Sawyer D.B., Colucci W.S.: MEK1/2-ERK1/2 mediates a1-adrenergic receptor stimulated hypertrophy in adult rat ventricular myocytes. J. Mol. Cell. Cardiol. 33:779-787, 2001.

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