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Xinliang, Ma M.D.

Thomas Jefferson University
Philadelphia, PA 19107
(215) 955-4994(Office)
Not available

Affiliation with

Lifetime member

Affiliation with

Lifetime member

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Xin-Liang Ma received his MD degree in 1982 (Shanxi Medical University, China) and PhD degree in 1988 (Fourth Military Medical University, China). Following his postdoctoral training from 1989 to 2002 in Department of Physiology at Thomas Jefferson University, he was recruited to the Department of Surgery as an Assistant Professor in 1993. He was promoted to Associate Professor in 1997 and Professor in 2002. He is currently a Tenured Professor at Thomas Jefferson University, Philadelphia and serves as the Director of Cardiovascular Research Program in Department of Emergency Medicine.  He has published more than 180 scientific research papers in peer-reviewed journals including Journal of Clinical Investigation, PNAS, Circulation, and Circulation Research. His works have been cited by other investigators in the field more than 6,000 times. He has been a member of the study section for the NIH, American Heart Association and American Diabetes Association. His research projects have been continually supported by NIH, ADA and AHA since 1999. He is an editorial member of Circulation Research and the American Journal of Physiology. He is interested in identifying the signaling mechanisms responsible for post-ischemic myocardial apoptosis with special emphasis on oxidative/nitrative stress and post-translational protein modification.

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马新亮,1988 年在第四军医大学获博士学位,1989 年赴美国Thomas Jefferson 大学从事博士后研究,随后留校分别任助教授(1993)、副教授(1997)和教授(2002)。现为Thomas Jefferson大学急诊医学系研究中心主任、终身教授,美国NIH、美国心脏学会(AHA)和美国糖尿病学会(ADA)基金评审委员会委员;Circulation Research, American Journal of Physiology 编委,Nature Medicine、Circulation 等十多种国际著名期刊的评审专家;1998 年国家杰出青年基金获得者(海外),2005 年教育部长江学者讲座教授。马新亮教授主要从事缺血性心脏病心肌损伤的发病机制与防治研 究。近五年主持了美国NIH 基金、AHA 和ADA 研究基金 等多项课题;发表SCI 论文180 多篇,其中以第一或通讯作者在Nature Cardiovascular Practice, Journal of Clinical Investigation 、PNAS 、 Circulation 及JACC 等国际著名期刊(影响因子>10)发表三十余篇, 他引次数愈6000次。

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Selected publication

1.       Ma XL, Tsao PS, Lefer AM. Antibody to CD-18 exerts endothelial and cardiac protective effects in myocardial ischemia and reperfusion.  J Clin Invest,  88:1237-1243, 1991.  PMID: 1680879.

2.       Ma XL, Weyrich AS, Lefer DJ, Buerke M, Kishimoto TK, Lefer AM. Monoclonal antibody to L-selectin attenuates neutrophil accumulation and protects ischemic reperfused cat myocardium.  Circulation, 88:649-658, 1993. PMID: 7687936

3.       Ma XL, Weyrich AS, Lefer DJ, Lefer AM. Diminished basal NO release and neutrophil-endothelium adherence following myocardial ischemia and reperfusion.  Circ Res., 72:403-412, 1993.  PMID: 8418991

4.       Gao F, Gao EH, Christopher TA, Lopez BL, Ma XL. Nitric Oxide Mediates the Antiapoptotic Effect of Insulin in Myocardial Ischemia-Reperfusion: The Roles of PI3-Kinase, Akt, and Endothelial Nitric Oxide Synthase Phosphorylation, Circulation, 105:1497-1502, 2002.  PMID: 11914261

5.       Liu HR, Gao E, Tao L, Hu AH, Qu Y, Christopher TA, Lopez BL,  Koch WJ, Zervos AS, Ma XL. Role of Omi/HtrA2 in Apoptotic Cell Death after Myocardial Ischemia and Reperfusion. Circulation. 111:90-96, 2005. PMID: 15611365

6.       Tao L, Jiao XY, Gao ER, Lau W, Lopez BL, Christopher TA, Rao S, William W, Southan G, Sharma K, Koch WJ, Ma XL. Nitrative Inactivation of Thioredoxin-1 and Its Role in Post-Ischemic Myocardial Apoptosis. Circulation, 114:1395-1402, 2006. PMID: 16966583

7.       Tao L, Gao ER, Jiao XY, Christopher TA, Lopez BL, Koch WJ, Chan L, Goldstein B, Ma XL. Adiponectin Cardioprotection After Myocardial Ischemia/Reperfusion Involves the Reduction of Oxidative/Nitrative Stress Circulation. 115:1408-1416, 2007. PMID: 17339545

8.       Wang YJ, Gao EH, Tao L, Lau WB, Yuan YX, Goldstein BJ, Lopez BL, Christopher TA, Tian R, Koch W, Ma XL. AMPK Deficiency Enhances Myocardial Ischemia/Reperfusion Injury but has Minimal Effect on Adiponectin’s Anti-Oxidant/Anti-Nitrative Protection. Circulation, 119:835-844, 2009.  PMID: 19188503

9.       Tao L, Wang YJ, Gao EH, Zhang HX, Yuan YX, Lau WB, Chan L, Koch WJ, Ma XL. Adiponectin: An Indispensable Molecule in Rosiglitazone Cardioprotection Following Myocardial Infarction.  Circ Res, 106:409-417, 2010. PMID: 19940263

10.    Wang YJ, Wang XL, Jasmin JF, Lau WB, Li R, Yuan XY, Yi W, Chuprun K, Lisanti MP, Koch W, Gao EH, Ma XL. Essential Role of Caveolin-3 in Adiponectin Signalsome Formation and Adiponectin Cardioprotection. Arterioscl Throm Vas Bio, published online February 9, 2012.  PMID: 22328772

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