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Yuxin, Fan M.D.

Baylor College of Medicine and Texas Children's Hospital
Houston, TX 77030
(832) 824-4155(Office)
Not available

Affiliation with

Lifetime member
Treasurer (2012-2013)
Chair, Cardiovascular Genetics (2012-2013)

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Dr. Yuxin Fan received his medical training and PhD degree in Genetics at Fudan University in China. He did his post-doctoral training, medical genetic fellowship and then was a junior faculty in the University of Washington School of Medicine from 1999 to 2007. He moved to Baylor College of Medicine in 2007. Dr. Fan currently is Director of the John Welsh Cardiovascular Diagnostic Laboratory and Assistant Professor at Department of Pediatrics-Cardiology, Texas Children's Hospital, Baylor College of Medicine. He is board-certified by the American Board of Medical Genetics (ABMG). He is a fellow of the American College of Medical Genetics (ACMG) and a member of the American Society of Human Genetics (ASHG) and American Heart Association (AHA). His research is focused on cardiovascular genetics, especially congenital heart disease, long QT syndrome/arrhythmia, and cardiomyopathy. Clinically, he is interested in the development and implementation of diagnostic tests for acquired and genetic forms of cardiac disease including, but not limited to, Marfan syndrome, Loeys-Dietz syndrome, familial thoracic aortic aneurysm/dissection (TAAD), Barth syndrome, dilated or hypertrophic cardiomyopathy (DCM/HCM), left ventricular noncompaction (LVNC), congenital heart diseases (CHD), long QT Syndrome (LQTS), short QT Syndrome (SQTS) arrhythmia disorders, pulmonary arterial hypertension (PAH), arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C), etc.

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范玉新博士在中国接受医学教育、并在复旦大学获得遗传学博士学位。1999-2007年在华盛顿大学医学院从事博士后研究、医学遗传学专科培训而后成为高级教员。2007年受聘于美国著名贝勒(Baylor)医学院。目前,范教授是贝勒医学院得克萨斯儿童医院约翰威尔士心血管诊断实验室主任、小儿心脏科副教授。他于2007年通过美国医学遗传学执照(ABMG)委员会考试,并获得医学遗传学执业执照。范教授是美国医学遗传学学院(ACMG)和美国人类遗传学学会(ASHG)以及美国心脏学会(AHA)高级会员。其研究集中于心血管遗传学,特别是先天性心脏病、长QT综合征/心律失常和心肌病。临床方面,他关注诸多获得性心脏病的遗传特点,诸如马凡综合征、Loeys-Dietz综合征、家族性胸主动脉瘤/动脉夹层(TAAD)、Barth综合征、扩张型/肥厚性心肌病(DCM/HCM)、左室致密化不全(LVNC)、先天性心脏病(CHD)、长QT综合征(LQTS)、短QT综合征(SQTS)等心律失常、肺动脉高压(PAH)、致心律失常性右室发育不良/心肌病(ARVD/C)等等。范教授已在《Nature》、《PNAS》、《Hum Mol. Genet.》、《Am. J. Hum. Genet.》、《Genome Res.》等著名杂志发表论文及论文摘要80余篇,他还是多家杂志的评委。

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Selected publication

  1. Fan, Y., E. Linardopoulou, C. Friedman, E. Williams, B.J. Trask. (2002). Genomic structure and evolution of the ancestral chromosome fusion site in 2q13-2q14.1 and paralogous regions on other human chromosomes. Genome Research, 12:1663-1672. PMID: 12421751
  2. Fan, Y., T. Newman, E. Linardopoulou, B.J. Trask. (2002). Gene content and function of the ancestral chromosome fusion site in human chromosome 2q13-2q14.1 and paralogous regions. Genome Research, 12:1651-1662. PMID: 12421752
  3. Fan, Y., L. Yu, Y.Z. Han, M.S. Ren, R.M. Yang, S.Y. Zhao. (2004). Identification of Three Novel Insertion/Deletion Mutations in Wilson Disease’s Gene. Biochemical Genetics, 42: 377-384. PMID: 15524314
  4. Ohtake H., P. Limprasert, Y. Fan, O. Onodera, A. Kakita, H. Takahashi, L.T. Bonner, D.W. Tsuang, I.V.J. Murray, V.M.-Y. Lee, J.Q. Trojanowski, A. Ishikawa, J. Idezuka, M. Murata, T. Toda, T.D. Bird, J.B. Leverenz, S. Tsuji, A.R. La Spada. (2004). -Synuclein gene alterations in dementia with Lewy bodies. Neurology, 63: 805-811. PMID: 15365127
  5. Linardopoulou, E., E. Williams, Y. Fan, C. Friedman, J. Young, B.J. Trask. (2005). Human subtelomeres: hot spots of inter-chromosomal segmental duplication and gene conversion. Nature, 437: 94-100. PMID: 16136133
  6. Palhan, V.B., S. Chen, G.H. Peng, A. Tjernberg, A.M. Gamper, Y. Fan, B.T. Chait, A.R. La Spada, R.G. Roeder. (2005). Polyglutamine-expanded ataxin-7 inhibits STAGA histone acetyltransferase activity to produce retinal degeneration. Proc Natl Acad Sci USA, 102:8472-8477. PMID: 15932940
  7. Fan, Y., P. Limprasert, I.V.J. Murray, A.C. Smith, V.M.-Y. Lee, J.Q. Trojanowski, B.L. Sopher, A.R. La Spada. (2006). -Synuclein modulates -synuclein neurotoxicity by reducing -synuclein protein expression. Hum Mol Genet. 15(20):3002-11. PMID: 16959793
  8. Singh HR, Yang Z, Siddiqui S, Pe?a LS, Westerfield BH, Fan Y, Towbin JA, Vatta M. A novel Alu-mediated Xq28 microdeletion ablates TAZ and partially deletes DNL1L in a patient with Barth syndrome. Am J Med Genet A. 2009 May;149A(5):1082-5. doi: 10.1002/ajmg.a.32822. PMID: 19396829
  9. Villamizar C, Regalado ES, Fadulu VT, Hasham SN, Gupta P, Willing MC, Kuang SQ, Guo D, Muilenburg A, Yee RW, Fan Y, Towbin J, Coselli JS, LeMaire SA, Milewicz DM. Paucity of skeletal manifestations in Hispanic families with FBN1 mutations. Eur J Med Genet. 2010 Mar-Apr;53(2):80-4. doi: 10.1016/j.ejmg.2009.11.001. Epub 2009 Nov 23. PMID: 19941982
  10. Yang Z, Funke BH, Cripe LH, Vick GW 3rd, Mancini-Dinardo D, Pe?a LS, Kanter RJ, Wong B, Westerfield BH, Varela JJ, Fan Y, Towbin JA, Vatta M. LAMP2 microdeletions in patients with Danon disease. Circ Cardiovasc Genet. 2010 Apr;3(2):129-37. PMID: 20173215
  11. Wang H, Li Z, Wang J, Sun K, Cui Q, Song L, Zou Y, Wang X, Liu X, Hui R, Fan Y. Mutations in NEXN, a Z-Disc Gene, Are Associated with Hypertrophic Cardiomyopathy. Am J Hum Genet. 2010 Nov 12;87(5):687-93. Epub 2010 Oct 21. PMID: 20173215 (Corresponding)
  12. Potter KJ, Creighton S, Armstrong L, Eydoux P, Duncan W, Penny DJ, Fan Y, Gibson WT. The c.7409G>A (p.Cys2470Tyr) Variant of FBN1: Phenotypic Variability across Three Generations. Mol Syndromol. 2013 Mar;4(3):125-35. doi: 10.1159/000347163. Epub 2013 Feb 28. PMID: 23653584 (Co-corresponding)
  13. Molina KM, Garcia X, Denfield SW, Fan Y, Morrow WR, Towbin JA, Frazier EA, Nelson DP. Parvovirus B19 myocarditis causes significant morbidity and mortality in children. Pediatr Cardiol. 2013 Feb;34(2):390-7. doi: 10.1007/s00246-012-0468-4. Epub 2012 Aug 8. PMID: 22872019
  14. Fan Y, Steller J, Gonzalez IL, Kulik W, Fox M, Chang R, Westerfield BA, Batra AS, Wang RY, Gallant NM, Pena LS, Wang H, Huang T, Bhuta S, Penny DJ, McCabe ER, Kimonis VE. A Novel Exonic Splicing Mutation in the TAZ (G4.5) Gene in a Case with Atypical Barth Syndrome. JIMD Rep. 2013 Apr 19. [Epub ahead of print]. PMID: 23606313
  15. Cecchi AC, Ogawa N, Carlson AA, Fan Y, Penny DJ, Guo DC, Eisenberg SB, Safi HJ, Estrera AL, Lewis RA, Meyers DE, Hennekam RC, Milewicz DM. Missense Mutations in FBN1 Exons 41 and 42 Cause Weill-Marchesani Syndrome with Thoracic Aortic Disease and Marfan Syndrome. Am J Med Genet A. 2009 (in press)
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