Clinical Science Building, Room: 920-N, M/C: 719
840 South Wood Street
Chicago, IL 60612
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AFFILIATION WITH www.CNAHA.org
Chair, International Affairs (2012-2013)
Dr. Lei Xiao graduated from Beijing Medical University (Beijing, China) in 1993 with a major in Clinical Medicine. He received his Ph.D. in Pharmacology from the Department of Pharmacology at the Creighton University School of Medicine (Omaha, NE) in 1998, where he first cloned the gene of the mouse α1A-adrenergic receptor during his Ph.D. studies. He completed his postdoctoral fellow training in Cardiovascular Diseases in Division of Cardiology at the Boston University School of Medicine (Boston, MA) in June 2001, and joined the faculty in the Division of Cardiology at Boston University as an Instructor in Medicine, and then became an Assistant Professor of Medicine in 2002. In 2004, Dr. Xiao relocated his lab to the University of Illinois at Chicago (UIC, Chicago, IL), where he first served as a Research Assistant Professor of Physiology and Medicine, and then a tenure-track Assistant Professor of Medicine in 2008.
Currently, Dr. Xiao is a tenure-track Assistant Professor in the Department of Medicine (Sections of Pulmonary, Critical Care, Sleep and Allergy; & Cardiology), and the Center for Cardiovascular Diseases (CCVR) at UIC. He is also the Director for Research Education in PCCSA section, and the Principle Investigator of two NIH R01 grants, one AHA National Scientist Development Grant, and several other intramural research grants. He is also the Co-investigator of three NIH R01 grants and three NIH S10 grants with other investigators. The research interests of Dr. Xiao's lab focus on the role of NADPH oxidase (NOX) and reactive oxygen species (ROS) in cardiac hypertrophy and heart failure, as well as the signal transduction pathways in cardiac myocytes and macrophages.
Dr. Xiao has received over 15 national and international awards for his research achievement. In 1999 and 2000, he received the First Place Award two years in a row at the annual AstraZeneca New England Cardiovascular Research Competition. In 2001, he was awarded the prestigious Jay N. Cohn New Investigator Award from the Heart Failure Society of America (HFSA). He has been a member of the American Heart Association (AHA) since 1997, and received the BCVS Travel Grant Award from the AHA Council on Basic Cardiovascular Sciences (BCVS) in 2011.
SELECTED JOURNAL ARTICLES (FROM OVER 70 PUBLICATIONS):
• Zhao G, Yu R, Deng J, Zhao Q, Christman JW, van Breemen RB, Xiao L: Pivotal role of reactive oxygen species in regulating lipopolysaccharide-induced prostaglandin D2 production in macrophages. J Biol Chem, In Press, 2012.
• Deng J, Wang X, Qian F, Vogel S, Xiao L, Ranjan R, Park H, Karpurapu M, Frey RS, Park GY, Ye RD, Christman JW: Protective role of reactive oxygen species in endotoxin-induced lung inflammation through modulation of IL-10 expression. J Immunol, In Press, 2012.
• Karpurapu M, Wang M, Deng J, Park H, Xiao L, Sadikot RT, Frey RS, Maus UA, Park GY, Scott E, Christman JW: Functional PU.1 in macrophages has a pivotal role in NF-κB activation and neutrophilic lung inflammation during endotoxemia. Blood, 118(19):5255-66, 2011. PMID: 21937699
• Yu R, Xiao L, Zhao G, Christman JW, van Breemen RB: Competitive enzymatic interactions contributing to the relative production of prostaglandins E2 and D2. J. Pharmacol. Exp. Ther., 339(2):716-725. 2011.
• Xiao L, Zhao Q, Du Y, Chao Y, Solaro RJ, Buttrick PM: PKCε increases phosphorylation of cardiac myosin binding protein C at serine302 both in vitro and in vivo. Biochemistry 46(23):7054-7061, 2007
• Maytin M, Siwik DA, Ito M, Xiao L, Sawyer DB, Liao R, Colucci WS.: Pressure overload-induced myocardial hypertrophy in mice does not require gp91phox. Circulation 109(9):1168-71, 2004.
• Xiao L., Pimentel D.R., Wang J., Singh K., Colucci W.S., Sawyer D.B.: Role of reactive oxygen species and NAD(P)H oxidase in α1-adrenoceptor signaling in adult rat cardiac myocytes. Am J Physiol Cell Physiol, 282:C926-C934, 2002.
• Xiao L., Pimental D.R., Amin J.K., Singh K., Sawyer D.B., Colucci W.S.: MEK1/2-ERK1/2 mediates α1-adrenergic receptor stimulated hypertrophy in adult rat ventricular myocytes. J. Mol. Cell. Cardiol. 33:779-787, 2001.
• Amin J.K., Xiao L., Pimental D.R., Patrick P.J., Sawyer D.B., Colucci W.S.: Reactive oxygen species mediate alpha-adrenergic receptor-stimulated hypertrophy in adult rat ventricular myocytes. J. Mol. Cell. Cardiol. 33:131-139, 2001.
• Pimentel D.R., Amin J.K., Xiao L., Miller T, Viereck J., Oliver-Krasinski J., Baliga R., Wang J., Siwik D.A., Singh K., Pagano P., Colucci W.S., Sawyer D.B.: Reactive oxygen species mediate amplitude-dependent hypertrophic and apoptotic responses to mechanical stretch in cardiac myocytes. Circ. Res. 89:453-460, 2001.
• Xiao L., Scofield M.A., Jeffries W.B.: Molecular cloning, expression and characterization of cDNA encoding a mouse α1a-adrenoceptor. Br. J. Pharmacol., 124:213-221, 1998"