Biography Li Zhang, MD Position Titles and Honors Director, Cardiovascular Outcomes Research, Cardiology, Lankenau Medical Center Associate Professor, Jefferson Medical College and Lankenau Institute for Medical Research Adjunct Professor, 1st Affiliated Hospital of Xi’an Jiaotong University Guest Professor, Institute of Molecular Medicine, Peking University, China Address Lankenau Medical Center 558 MOB East 100 Lancaster Avenue Wynnewood, PA 19096 U.S.A. Email: ldlzhang@gmail.com Web page: www.limr.org/lmr/Page.asp?out=html&searchType=Faculty&PageID=LMR000199 Affiation with www.CNAHA.org Lifetime member Chair, Electrophysiology (2009-2011) Vice President (2012-2013) As one of 77(5) class graduates of Xi’an Medical University, Dr. Li Zhang completed her medical residency and cardiology training at the 2nd Affiliated Hospital of Xi’an Jiaotong University. She started full-time clinical research in 1994 at LDS Hospital, Salt Lake City, Utah, USA and has become a renowned expert in investigating inherited arrhythmias associated with increased risks of sudden death in young but otherwise healthy individuals. She is a principal investigator and a collaborator in studies of arrhythmogenic right ventricular dysplasia (ARVD) and long QT syndrome (LQTS) sponsored by AHA and NIH, respectively. Dr. Zhang’s primary goal in research is to improve the early diagnosis of lethal heart rhythm disorder for prompt medical intervention and sudden death prevention. She is an author/co-author of greater than 150 research manuscripts and abstracts with the vast majority of publications in SCI journals. She has made important contributions in establishing the ongoing registry studies in China for LQTS, ARVD and left ventricular noncompaction. Besides productive research, Dr. Zhang has facilitated various US-China medical exchange programs. For medical education, she and the team which she organized made great success in delivering a series of ISHNE world-wide cardiology symposiums to China in 2007-2010. 作为西安医科大学医疗系77（5）级的一名本科毕业生，张莉留校在西安交通大学第二附属医院完成了住院医师,住院总医师和心脏科培训,从事心脏主治医工作。她于1994年开始在犹他州盐湖城LDS医院从事专职临床研究，并成为研究青少年健康人群突然死亡风险增加相关遗传性心律失常的知名专家。她和她的合作者分别获得美国心脏学会（AHA）和美国卫生研究院（NIH）科研基金资助研究致心律失常性右室发育不良（ARVD）和长QT综合征（LQTS）。张莉从事心律失常研究的主要目的是提高对致命性心律紊乱早期诊断水平，从而给予及时的医疗干预以预防心律失常导致的猝死。作为第一作者和合作者，她有150多篇研究论文或论文摘要绝大多数在SCI收录的出版物上发表。她对建立中国LQTS，ARVD及左心室致密化不全注册研究作出了重要贡献。在学术研究之外，张莉还积极促进各种中美医学交流计划。在医学教育领域，她和她领导的团队在2007-2010年，成功地给中国同行呈现出一系列国际动态心电图和无创性心电协会(ISHNE)组织的国际心脏病网上论坛研讨大会。 Selected publications Zhang L, Timothy KW, Vincent GM, Lehmann MH, Fox J, Giuli LC, Shen J, Priori SG, Compton SJ, Yanowitz F, Benhorin J, Moss AJ, Schwartz PJ, Robinson JL, Wang Q, Zareba W, Keating MT, Towbin JA, Napolitano C, Medina A: The Spectrum of ST-T Wave Patterns and Repolarization Parameters in Congenital Long QT Syndrome: ECG Findings Identify Genotypes. Circulation 2000;102:2849-2855. PMID: 11104743 Zhang L, Vincent GM, Baralle M, Baralle FE, Anson B, Benson DW, Whiting B, Timothy KW, Carlquist J. January CT, Keating MT, Splawski I. An Intronic Mutation Causes Long QT Syndrome. J Am Coll Cardiol 2004;44-1283-91. PMID: 15364333  Zhang L, Benson DW, Tristani-Firouzi M, Ptacek LJ, Tawil R, Schwartz PJ, George AL, Horie Minoru, Anderlfinger G, Fu YH, Ackerman MJ Vincent GM. ECG Features in Patients with KCNJ2 Mutations: Characteristic T-U Wave patterns Predict Genotype. Circulation 2005;111:2720-2726. PMID: 15911703 Gong Q, Zhang L, Vincent GM, Horne BD, Zhou ZF. Nonsense Mutations in hERG Cause a Decrease in Mutant mRNA Transcripts by Nonsense-mediated mRNA Decay in Human Long QT Syndrome. Circulation 2007,116(1):17-24. PMCID: PMC2376840 Gong Q, Zhang L, Moss AJ, Vincent GM, Ackerman MJ, Robinson JC, Jones MA, Tester DJ, and Zhou ZF. Cryptic splicing caused by a splice site mutation in hERG leads to a large in-frame insertion in long QT syndrome. J Mol Cell Cardiol. 2008;44(3):502-9. PMCID: PMC2346779 Goldenberg I, Moss AJ, Peterson DR, McNitt S, Zareba W, Andrew ML, Robinson JL, Locati EH, Ackerman MJ, Benhorin J, Kaufman ES, Napolitano C, Priori SG, Qi M, Peter J. Schwartz PJ, Towbin JA, Vincent, Zhang L. Risk factors for aborted cardiac arrest and sudden cardiac death in children with the congenital long-QT syndrome. Circulation 2008;117(17)2184-91. PMID: 18427136 Vincent GM, Schwartz, PJ, Denjoy,I, Swan H, Bithell C, Spazzolini C, Crotti L, Piippo K, Lupoglazoff JM, Villain E, Priori SG, Napolitano C, Zhang L. High Efficacy of Beta-Blockers in Long QT syndrome Type 1: Contribution of non-compliance and QT prolonging drugs in the occurrence of Beta-blocker “failure”. Circulation 2009, 20;119(2):215-21. PMID: 19118258 Qiu XL, Liu WL, Hu DY, Zhu TG, Li CL, Li L, Zhang L. Novel plakophilin-2 mutations in symptomatic Chinese patients with arrhythmogenic right ventricular dysplasia. Amer J Cardiol 2009,103:1439-1444. PMID: 19427443 Goldenberg I, Horr S, Moss AJ, Lopes CM, Barsheshet A, McNitt S, Zareba W, Andrews ML, Robinson JL, Locati EH, Ackerman MJ, Benhorin J, Kaufman ES, Napolitano C, Platonov PG, Priori SG, Qi M, Schwartz PJ, Shimizu W, Towbin JA, Vincent GM, Wilde AA, Zhang L. Risk for life-threatening cardiac events in patients with genotype-confirmed long-QT syndrome and normal-range corrected QT intervals. J Am Coll Cardiol 2010;57(1):51-9.10. PMID: 21185501 Zarraga IGE, Zhang L, Stump M, Gong QM, Vincent GM, Zhou ZF. Phenotype-Genotype Correlation in a Large Kindred of Type 2 Long QT Syndrome Caused by a Frameshift Mutation Producing Nonsense-Mediated mRNA Decay. Heart Rhythm Journal 2011;8(8):1200-6. PMID: 21419236