Biography Yuxin Fan, MD, PhD, FACMG Director, John Welsh Cardiovascular Diagnostic Laboratory Assistant Professor, Department of Pediatrics-Cardiology Texas Children's Hospital Baylor College of Medicine 1102 Bates Avenue, Feigin Center Suite 430.09 Houston, TX 77030 USA Phone: 832-824-4155 Fax: 832-825-5159 Email: yuxinf@bcm.edu Website: www.bcm.edu/pediatrics/welsh Affiliation with www.CNAHA.org Lifetime member Treasure (2012-2013) Chair, Cardiovascular Genetics (2012-2013) Dr. Yuxin Fan received his medical training and PhD degree in Genetics in China. He did his post-doctoral training, medical genetic fellowship and then was a junior faculty in the University of Washington School of Medicine from 1999 to 2007. He moved to Baylor College of Medicine in 2007. Dr. Fan currently is an Assistant Professor and Laboratory Director at the John Welsh Cardiovascular Diagnostic Laboratory, Department of Pediatrics-Cardiology, Texas Children's Hospital, Baylor College of Medicine. He is board-certified by the American Board of Medical Genetics (ABMG). He is a fellow of the American College of Medical Genetics (ACMG) and a member of the American Society of Human Genetics (ASHG) and American Heart Association (AHA). His research is focused on cardiovascular genetics, especially congenital heart disease, long QT syndrome/arrhythmia, and cardiomyopathy. Clinically, he is interested in the development and implementation of diagnostic tests for acquired and genetic forms of cardiac disease including, but not limited to, Marfan syndrome, Loeys-Dietz syndrome, familial thoracic aortic aneurysm/dissection (TAAD), Barth syndrome, dilated or hypertrophic cardiomyopathy (DCM/HCM), left ventricular noncompaction (LVNC), congenital heart diseases (CHD), long QT Syndrome (LQTS), short QT Syndrome (SQTS) arrhythmia disorders, pulmonary arterial hypertension (PAH), arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C), etc. 范玉新，医学学位，博士，美国医学遗传学基金会会员 贝勒医学院得克萨斯儿童医院小儿心脏科副教授、 约翰威尔士心血管诊断实验室主任 Bates 大街102号，Feigin 中心430.09室， 美国得克萨斯州，休斯顿，77030 范博士在中国接受医学教育、并获得遗传学博士学位。1999-2007年在华盛顿大学医学院从事博士后研究、医学遗传学专科培训而后成为高级教员。2007年转到贝勒医学院。 目前，范博士是贝勒医学院得克萨斯儿童医院小儿心脏科副教授、约翰威尔士心血管诊断实验室主任。他获得美国医学遗传学(ABMG)委员会认证，并成为美国医学遗传学学会(ACMG)和美国人类基因组学学会(ASHG)以及美国心脏病学会会员。其研究集中于心血管遗传学，特别是先天性心脏病、长QT综合征/心律失常和心肌病。临床方面，他关注诸多获得性心脏病的遗传特点，诸如马凡综合征、Loeys-Dietz综合征、家族性胸主动脉瘤/动脉夹层(TAAD)、Barth综合征、扩张型/肥厚性心肌病(DCM/HCM)、左室致密化不全(LVNC)、先天性心脏病(CHD)、长QT综合征(LQTS)、短QT综合征(SQTS)等心律失常、肺动脉高压（PAH）、致心律失常性右室发育不良/心肌病(ARVD/C)等等。 Selected 10 Representative Publications: Fan, Y., L. Yu, Q. Tu, R.M. Gong, Y. Jiang, Q. Zhang, F.Y. Dai, C.Y. Chen, S.Y. Zhao. (2002). Molecular cloning, genomic organization, and mapping of 4GalT-VIb, a brain abundant member of 4-galactosyltransferase gene family, to human chromosome 18q12.1. DNA Sequence, 13:1-8. PMID: 12180132 Fan, Y., E. Linardopoulou, C. Friedman, E. Williams, B.J. Trask. (2002). Genomic structure and evolution of the ancestral chromosome fusion site in 2q13-2q14.1 and paralogous regions on other human chromosomes. Genome Research, 12:1663-1672. PMID: 12421751 Fan, Y., T. Newman, E. Linardopoulou, B.J. Trask. (2002). Gene content and function of the ancestral chromosome fusion site in human chromosome 2q13-2q14.1 and paralogous regions. Genome Research, 12:1651-1662. PMID: 12421752 Fan, Y., L. Yu, Y.Z. Han, M.S. Ren, R.M. Yang, S.Y. Zhao. (2004). Identification of Three Novel Insertion/Deletion Mutations in Wilson Disease’s Gene. Biochemical Genetics, 42: 377-384. PMID: 15524314 Ohtake H., P. Limprasert, Y. Fan, O. Onodera, A. Kakita, H. Takahashi, L.T. Bonner, D.W. Tsuang, I.V.J. Murray, V.M.-Y. Lee, J.Q. Trojanowski, A. Ishikawa, J. Idezuka, M. Murata, T. Toda, T.D. Bird, J.B. Leverenz, S. Tsuji, A.R. La Spada. (2004). -Synuclein gene alterations in dementia with Lewy bodies. Neurology, 63: 805-811. PMID: 15365127 Linardopoulou, E., E. Williams, Y. Fan, C. Friedman, J. Young, B.J. Trask. (2005). Human subtelomeres: hot spots of inter-chromosomal segmental duplication and gene conversion. Nature, 437: 94-100. PMID: 16136133 Palhan, V.B., S. Chen, G.H. Peng, A. Tjernberg, A.M. Gamper, Y. Fan, B.T. Chait, A.R. La Spada, R.G. Roeder. (2005). Polyglutamine-expanded ataxin-7 inhibits STAGA histone acetyltransferase activity to produce retinal degeneration. Proc Natl Acad Sci USA, 102:8472-8477. PMID: 15932940 Fan, Y., P. Limprasert, I.V.J. Murray, A.C. Smith, V.M.-Y. Lee, J.Q. Trojanowski, B.L. Sopher, A.R. La Spada. (2006). -Synuclein modulates -synuclein neurotoxicity by reducing -synuclein protein expression. Hum Mol Genet. 15(20):3002-11. PMID: 16959793 Yang Z, Funke BH, Cripe LH, Vick GW 3rd, Mancini-Dinardo D, Peña LS, Kanter RJ, Wong B, Westerfield BH, Varela JJ, Fan Y, Towbin JA, Vatta M. LAMP2 microdeletions in patients with Danon disease. Circ Cardiovasc Genet. 2010 Apr;3(2):129-37. PMID: 20173215 Wang H, Li Z, Wang J, Sun K, Cui Q, Song L, Zou Y, Wang X, Liu X, Hui R, Fan Y. Mutations in NEXN, a Z-Disc Gene, Are Associated with Hypertrophic Cardiomyopathy. Am J Hum Genet. 2010 Nov 12;87(5):687-93. Epub 2010 Oct 21. PMID: 20173215