Zhongjie Sun, MD, PhD, FAHA
Professor of Physiology
Director, The Robert & Mary Cade Laboratory
University of Oklahoma Health Sciences Center
BMSB 662A, Box 26901
Oklahoma City, Oklahoma 73190
Tel. 405-271-2226 ext. 56237
Fax. 405-271-3181
e-mail. zhongjie-sun@ouhsc.edu
Affiliation with www.theACRE.org
Lifetime member
President, the Academy of Cardiovascular Research Excellence (ACRE) (2010-2012)
Dr. Zhongjie Sun is currently a tenured professor and the Director of the Robert & Mary Cade Laboratory in the Department of Physiology at the University of Oklahoma Health Sciences Center. Dr. Sun received PhD in Physiology from the joint education program of Shanghai Medical University and University of Florida. He had postdoctoral training in cardiovascular (CV) physiology at the University of Florida. His research interest is molecular mechanism of hypertension and molecular therapy for cardiovascular disease. His long-term goal is to identify and characterize new genes that are involved in cardiovascular disease for the purpose to develop preventive strategies and therapeutic approaches. He is particularly interested in the development of animal models of human CV and metabolic diseases and the investigation of new signaling pathways and therapeutic mechanisms of these diseases. Dr. Sun published extensively in these areas. His research has been continuously supported by the National Institute of Health (NIH) and American Heart Association (AHA). He currently serves on the editorial board of Hypertension and Physiological Genomics. Dr. Sun also serviced in several national and international grant review panels for NIH, AHA, National Science Foundation, Department of Defense, American Institute of Biological Sciences, Canada Foundation of Innovation, and Wellcome Trust Foundation, and US Army and Navy. Dr. Sun currently is President of the Academy of Cardiovascular Research Excellence (ACRE) and Chair of the APS Physiological Genomics Group.
孙中杰, 医学博士，哲学博士
美国俄克拉何马大学医学院生理学教授
Robert & Mary Cade实验室主任
孙中杰, 医学搏士 (MD), 哲学搏士 (PhD, 上海医科大学及美国佛罗里达大学), 现任美国俄克拉荷马大学医学中心 Robert and Mary Cade 实验室主任，医学院生理学系终身教授。
孙中杰博士主要从事心血管生理学，药理学，高血压 及分子心脏病学研究。他在高血压的分子发病机制及高血压的基因治疗方面有着深入和全面的探讨。近年来，他在高血压的长期控制方面进行了开拓性的研究。目前孙博士的研究项目包括炎症 (inflammation）, RNA 干扰 (RNA interference), 和氧化应激 (oxidative stress) 在高血压及动脉硬化发病中的作用。 他的研究团队首先发现了抗衰老基因 klotho 和高血压之间的关系。他的研究表明klotho 是一个治疗高血压的新靶点。孙博士的研究课题一直受到美国国家心脏学会 (AHA) 及美国国立卫生研究院 (NIH) 的资助。他是美国国家自然科学基金 (NSF) 评审委员会委员，美国国立卫生研究院 (NIH) 科学基金评审委员会委员，美国国防部 (Department of Defense) 医学研究基金评审委员会委员, 美国海军 (US Navy) 特种医学研究基金评审委员会委员, 及加拿大创新基金 会 (Canada Foundation of Innovation) 研究基金评审委员会委员。他是美国佛罗里达大学及俄克拉荷马大学研究基金评审委员会委员。
孙博士一直担任国际专业杂志(Circulation, Circ Res, Hypertension) 的审稿人。他是分子心脏病学(Molecular Cardiology: Methods and Protocols) 的主编。他还是几个重要国际医学杂志编委会委员(Hypertension, Physiological Genomics）。他还受邀主持多次国际学术会议分会并作大会报告。孙博士目前是多个学术组织的成员并担任过职务，包括美国心脏学会 国际导师 (AHA International Mentor) 组成员，恩科心血管研究院 (ACRE) 会员资格审查委员会主任, 及美国生理学会 (APS）科学政策委员会委员。孙博士现在是恩科心血管研究院主席和美国生理学会APS Physiological Genomics Group 主席。
Selected Publications
1. Yuhong Wang and Zhongjie Sun. Klotho suppresses NADPH oxidase activity and
superoxide production in rat aortic smooth muscle cells. Aging Cell. (in press, 2012). 2012 Jan 19. doi: 10.1111/j.1474-9726.2012.00796.x. PMCID: 22260450.
2. Zhong Zuo, Han Lei, Xiuqing Wang, Yuhong Wang, William Sonntag and Zhongjie Sun. Aging-related renal damage is associated with decreased klotho expression and increased superoxide production. AGE. 33:261-274, 2011. PMCID: 20086041.
3. Patrick Crosswhite and Zhongjie Sun. RNA inhibition of interleukin-6 gene attenuates cold-induced hypertension. Hypertension. 55:1484-1491, 2010. PMCID: 20385973.
4. Xiuqing Wang and Zhongjie Sun. RNAi inhibition of brain klotho potentiates cold-induced
elevation of blood pressure via the endothelin pathway. Physiol Genom. 41:120-126, 2010. PMCID:
20086041
5. Yuhong Wang and Zhongjie Sun. In vivo klotho gene delivery prevents progression of
spontaneous hypertension and renal damage. Hypertension.54:810-817, 2009. PMCID:
19635988.
6. Xiuqing Wang and Zhongjie Sun. Thyroid hormone induces vascular smooth muscle cell proliferation: discovery of a new TRα1-Nox1 pathway. J Cell Mol Med. 14:368-380, 2010. PMCID 18774961.
7. Karigowda J. Dammanahalli and Zhongjie Sun. Endothelin-1 inhibits nicotinamide adenine
dinucleoyide phosphate oxidase activity in human abdominal aortic endothelial cells: a novel function of ETB1 receptors. Endocrinology. 149:4979-4987, 2008.
8. Mahajoub Bello Roufai, Hua Li and Zhongjie Sun. Heart-specific inhibition of proto-oncogene c-myc attenuates cold-induced cardiac hypertrophy. Gene Ther. 14:1406-1416, 2007. PMCID: 17637797
9. Xiuqing Wang, Lucille Skelley, Robert Cade and Zhongjie Sun. AAV delivery of mineralocorticoid receptor shRNA prevents progression of cold-induced hypertension and attenuates renal damage. Gene Ther. 13:1097-1103, 2006. PMCID: 16554840
10. Xiuqing Wang, Robert Cade and Zhongjie Sun. Prolonged attenuation of cold-induced hypertension by adenoviral delivery of renin antisense. Kidney Int. 68:680-687, 2005. PMCID: 16014045
